protein p53 การใช้

• Transcriptional activation of this gene can be induced by tumor protein p53.
• It also seems to be important for the regulation of the tumor suppressor protein p53.
• The protein p53 is believed to play a role in the development of resistance to chemotherapy.
• Ordinarily, Aurora A expression levels are kept in check by the tumor suppressor protein p53.
• This is because the X protein promotes cell cycle progression while binding to and inhibiting tumor suppressor protein p53 from performing their role.
• This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.
• In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis.
• The study showed that feeding a low concentration ( 0.5 % or 1 % ) of the mushroom extract enhanced the expression of the protein p53.
• The expression of " BAX " is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis.
• Beyond its function as a transcription factor, IRF-1 has also been shown to trans-activate the tumour suppressor protein p53 through the recruitment of its co-factor p300.
• It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
• The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G 1 phase arrest in response to a variety of stress stimuli.
• He was awarded the 1998 Louisa Gross Horwitz Prize for Biology or Biochemistry and was the first recipient of the Albany Medical Center Prize in Medicine and Biomedical Research in 2001 for his discovery of the tumor suppressor protein p53.
• In response to upregulation of tumor suppressor protein p53, C16-ceramide levels were increased in leukemia and colon cancer cells, as were levels of CerS5 mRNA in the leukemia cells, but not in the colon cancer cells.
• HPV associated cancers are caused by the expression of HPV's E6 and E7 proteins that bind to and inactivate tumor suppressor proteins p53 and retinoblastoma protein ( pRB ), respectively, leading to malignant transformation of HPV infected cells.
• This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA . The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells.
• Different transcription factors that have been reported responsible for the regulation of fhl2 expression include the well-known tumor suppressor protein p53, serum response factor ( SRF ), speci
  鹀ity protein 1 ( Sp1 ) . the pleiotropic factor IL-1?, MEF-2, Apart from being regulated by different transcription factors, FHL2 is itself involved extensively in regulating the expression of other genes.
• Examples include the proteins involved in Alzheimer's disease-amyloid ?-protein ( A? ) and tau; ?-synuclein, which is thought to cause Parkinson s disease and other synucleinopathies and is involved in spinal-cord injury; islet amyloid polypeptide ( amylin ), which kills pancreatic ?-cells in type-2 diabetes; transthyretin ( TTR ), which causes familial amyloid polyneuropathy, familial amyloid cardiomyopathy, and senile systemic amyloidosis; aggregation-prone mutants of the tumor-suppressor protein p53; and semen proteins whose aggregation enhances HIV infection.